Attenuation of Exercise Induced Asthma by Nedocromil Sodium and Sodium Cromoglycate

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Attenuation of exercise induced asthma by nedocromil sodium and sodium cromoglycate.

A randomized double blind cross over trial to compare nedocromil sodium and sodium cromoglycate with placebo in the prevention of exercise induced asthma was conducted. Twenty asthmatics received nedocromil sodium, sodium cromoglycate or placebo via metered dose inhalers on successive days 30 minutes before exercise in a randomized order. Nedocromil sodium and sodium cromoglycate gave sufficien...

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Nedocromil sodium and exercise induced asthma.

Serial exercise tests were carried out by 12 children with asthma on two study days. After a control exercise test either nedocromil sodium 4 mg or placebo were given double blind by metered dose inhaler. Highly significant inhibition of exercise induced asthma occurred after nedocromil, lasting for over two hours.

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Nedocromil sodium and exercise induced asthma

Nedocromil sodium (Tilade) is a new anti-asthma drug that has selective mucosal mast cell stabilising properties.' In single dose human studies nedocromil has been shown to protect against exercise induced asthma,2 while in clinical studies, in which it has been administered four times a day for one month, improvements have been shown in the control of adult asthma.3 There are no published data...

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Dose duration of nebulized nedocromil sodium in exercise-induced asthma.

The dose-duration effect of nebulized nedocromil sodium was studied in ten patients with exercise-induced asthma (7 males mean (SEM) age 30.1 (3.5) yrs and predicted forced expiratory volume in one second (FEV1) 102%). All of these patients showed > 40% protection of their exercise asthma with 4 mg of nedocromil sodium delivered via metered dose inhaler. Three concentrations of nedocromil sodiu...

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Sodium cromoglycate and ipratropium bromide in exercise-induced asthma.

In thirteen patients with extrinsic asthma the effects of placebo, sodium cromoglycate, ipratropium bromide, and ipratropium bromide plus sodium cromoglycate were studied in a random double-blind fashion to assess their inhibitory action in exercise-induced asthma (EIA). Exercise testing consisted of steady state running on an inclined treadmill for up to eight minutes. In eight of the 13 patie...

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ژورنال

عنوان ژورنال: Journal of the Royal Army Medical Corps

سال: 1990

ISSN: 0035-8665,2052-0468

DOI: 10.1136/jramc-136-02-09